Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 15, Pages 4790-4799Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201809006
Keywords
cell function; cell surface receptor; clustering; integrin; nanotechnology
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Funding
- National Natural Science Foundation of China [21621003, 21235004, 21327806]
- Tsinghua University Initiative Scientific Research Program
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The spatial organization of cell-surface receptors plays an important role in defining cell fate. Recently, the development of strategies for the direct regulation of receptor clustering using nanomaterials has aroused enormous interest. In this review, we discuss the mechanisms and features of recently developed nanomaterial-based strategies to control the nanoscale distribution of cell binding ligands and regulate cell behavior. We expect this review to inspire innovative work on manipulating cell functions by controlling the clustering of cell surface receptors.
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