Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 48, Pages 15787-15791Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201810253
Keywords
alkene difunctionalization; azide; diazo compounds; enones; phosphine catalysis
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Funding
- 973 Programs [2015CB856600]
- National Natural Science Foundation of China [21425205]
- Changjiang Scholars and Innovative Research Team in University (PCSIRT)
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An efficient and practical phosphine-catalyzed vicinal difunctionalization of beta-fluoroalkyl alpha,beta-enones with TMSN3 has been developed. Using dppb as the catalyst, the reaction worked efficiently to yield various beta-amino alpha-diazocarbonyl compounds in high yields (up to 94%). This work marks the first efficient construction of alpha-diazocarbonyl compounds by phosphine catalysis. Meanwhile, the asymmetric variant induced by the nucleophilic bifunctional phosphine P4 led to various chiral fluoroalkylated beta-amino alpha-diazocarbonyl compounds in high yields and enantioselectivity. NMR and ESI-MS studies support the existence of the key reaction intermediates. In contrast, beta-azide carbonyl compounds would be furnished in good yields from beta-fluoroalkylated beta,beta-disubstituted enones.
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