Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 12, Pages 3834-3837Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813239
Keywords
aggregation-induced emission; cancer cells; cryosurgery; freezing; real-time imaging
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Funding
- National Key R&D Program of China [2018YFA0208502]
- Chinese National Nature Science Foundation [51673024, 51803009, 21733010, 21490574, 21421061, 21875261]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2018044]
- Beijing Institute of Technology Research Fund Program for Young Scholars
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Cryosurgery has attracted much attention for the treatment of tumors owing to its clear advantages. However, determining the volume of frozen tissues in real-time remains a challenge, which greatly lowers the therapeutic efficacy of cryosurgery and hinders its broad application for the treatment of cancers. Herein, we report a freezing-induced turn-on strategy for the selective real-time imaging of frozen cancer cells. As a type of aggregation-induced emission (ME) fluorogen, TABD-Py molecules interact specifically with ice crystals and form aggregates at the ice/water interface. Consequently, bright fluorescent emission appears upon freezing. TA BD-Py molecules are enriched mostly in the cancer cells and exhibit high biocompatibility as well as low cytotoxicily; therefore, a freezing-induced turn-on imaging modality for cryosurgery is developed, which will certainly maximize the therapeutic efficacy of cryosurgery in treating tumors.
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