Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 22, Pages 7180-7191Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812534
Keywords
catalysis; data analysis; flow chemistry; high throughput experimentation; synthetic methods
Categories
Funding
- Natural Science and Engineering Research Council of Canada (NSERC)
- University of Ottawa
- Canadian Foundation of Innovation (CFI)
- Canada Research Chairs program
- Ontario Ministry of Research, Innovation and Science
- NSERC
- Government of Ontario
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Homogeneous catalysis has provided chemists with numerous transformations to enable rapid construction of organic molecules. However, these reactions are complex, requiring multiple substrate-dependent mechanistic steps to operate in harmony under a single set of experimental conditions. As a consequence, synthetic chemists often carry out laborious, empirical screening to identify suitable catalysts, solvents, and additives to achieve high yields and selectivity. In this Minireview, recently developed tools, technologies, and strategies will be described that improve this development process. In particular, the application of high throughput techniques to run more experiments, experimental design principles to access better data, and statistical tools to provide predictive models will be discussed.
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