Visible-Light-Induced Pyridylation of Remote C(sp3)-H Bonds by Radical Translocation of N-Alkoxypyridinium Salts

Metal-free, visible-light-induced site-selective heter-oarylation of remote C(sp(3))-H bonds has been accomplished through the design of N-alkoxyheteroarenium salts serving as both alkoxy radical precursors and heteroaryl sources. The transient alkoxy radical can be generated by the single-electron reduction of an N-alkoxypyridinium substrate by a photo-excited quinolinone catalyst. Subsequent radical translocation of the alkoxy radical forms a nucleophilic alkyl radical intermediate, which undergoes addition to the substrate to achieve remote C(sp(3))-H heteroarylation. This cascade strategy provides a powerful platform for remote C(sp(3))-H heteroarylation in a controllable and selective manner and is well suited for late-stage functionalization of complex bioactive molecules.