Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 302, Issue 2, Pages 269-277Publisher
WILEY
DOI: 10.1002/ar.23945
Keywords
breast cancer; diabetes mellitus; mouse model; MMTV-PyMT transgenic mice
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Funding
- National Science Foundation of China [31500966, 81773095, 31471290]
- Science and Technology Planning Project of Guangdong Province [2014B020212012, 2014A020212314, 2015A020211029]
- Science and Technology Planning Project of Guangzhou City [201607010135]
- New Mechanisms of Major Diseases of Inflammation Creative Team [2016KCXTD019]
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Both diabetes and breast cancer are common diseases worldwide, and diabetes is also linked to higher rates of breast cancer. Epidemiological data also indicate that diabetes may be one of the risk factors for breast cancer. However, the effect of diabetes on breast cancer progression in vivo is rarely reported. We established an ideal animal model of breast cancer using transgenic MMTV-PyMT mice, which spontaneously developed breast cancer. In this model, the animals copresented with diabetes mellitus, which allowed us to study the effect of high glucose on breast cancer. Compared with MMTV-PyMT mice without diabetes, MMTV-PyMT mice with diabetes developed heavier tumors and exhibited greater tumor volumes. Furthermore, high glucose promoted the invasiveness and metastasis of breast cancer in MMTV-PyMT mice. This breast cancer model in which mice copresented with diabetes provides a useful tool to study the effect of diabetes on breast cancer. Anat Rec, 302:269-277, 2019. (c) 2018 Wiley Periodicals, Inc.
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