Journal
ANALYTICAL CHEMISTRY
Volume 90, Issue 21, Pages 13081-13087Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b04223
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21725504, 21675121, 21721005]
- Open Funds of the State Key Laboratory of Electroanalytical Chemistry [SKLEAC201706]
- China Postdoctoral Science Foundation [2017M620329, 2018T110790]
Ask authors/readers for more resources
Flexible electrochemical (EC) sensors have shown great prospect in epidermal detection for personal healthcare and disease diagnosis. However, no reports have been seen in flexible device for urea analysis in body fluids. Herein, we developed a flexible wearable EC sensor based on surface molecularly imprinted nanotubes for noninvasive urea monitoring with high selectivity in human sweat. The flexible EC sensor was prepared by electropolymerization of 3,4-ethylenedioxythiophene (EDOT) monomer on the hierarchical network of carbon nanotubes (CNTs) and gold nanotubes (Au NTs) to imprint template molecule urea. This sensor exhibited a good linear response toward physiologically relevant urea levels with negligible interferences from common coexisting species. Bending test revealed that this sensor possessed excellent mechanical tolerance and its EC performance was almost not affected by bending deformation. On-body results of human subjects showed that the flexible platform could distinctly respond to the urea levels in volunteer's sweat after aerobic exercise. The new flexible epidermal EC sensor can provide useful insights into noninvasive monitoring of urea levels in various biofluids, which is promising in the clinical diagnosis of diverse biomedical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available