Journal
ANALYTICA CHIMICA ACTA
Volume 1052, Issue -, Pages 124-130Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2018.11.030
Keywords
Through-bond energy transfer; Ratiometric; Fluorescent probe; HOCl; Lysosomal
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Funding
- Natural Science Foundation of China [21807078]
- Medical Science and Technology Development Plan Project of Shandong Province [2015WS0104]
- Natural Science Foundation of Shandong Province [ZR2016BB35, ZR2018LB014]
- Foundation of Taishan Medical University [2016GCC08]
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In this paper, we synthesized a ratiometric fluorescence probe (IRh-Ly) for lysosomal hypochlorous acid (HOCl) by adopting a through-bond energy transfer (TBET) strategy on rhodamine-imidazo[1,5-alpha]pyridine platform. IRh-Ly showed brilliant selectivity, rapid response for HOCl. The probe also exhibited high sensitivity with the detection limit calculated to be 10.2 nM. Moreover, we demonstrated its successful application of detecting lysosomal HOCl in living RAW264.7 cells. Notably, the morpholine was integrated into the fluorescent probe IRh-Ly and the results revealed that IRh-Ly could target lysosome and detect the lysosomal HOCl. All the unique features made IRh-Ly particularly suitable for ratiometric HOCl detection and bio-imaging applications. (C) 2018 Elsevier B.V. All rights reserved.
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