Related references
Note: Only part of the references are listed.Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine
Max Zhan et al.
BIOCHEMICAL JOURNAL (2014)
Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene
Shurong Hou et al.
BIOCHEMICAL JOURNAL (2014)
Long-Term Reduction of Cocaine Self-Administration in Rats Treated with Adenoviral Vector-Delivered Cocaine Hydrolase: Evidence for Enzymatic Activity
Natalie E. Zlebnik et al.
NEUROPSYCHOPHARMACOLOGY (2014)
Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine
Liu Xue et al.
BIOCHEMICAL JOURNAL (2013)
Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage
Yang Gao et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice
Stephen Brimijoin et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Substrate selectivity of high-activity mutants of human butyrylcholinesterase
Shurong Hou et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
Gene Transfer of Mutant Mouse Cholinesterase Provides High Lifetime Expression and Reduced Cocaine Responses with No Evident Toxicity
Liyi Geng et al.
PLOS ONE (2013)
Cocaine Hydrolase Encoded in Viral Vector Blocks the Reinstatement of Cocaine Seeking in Rats for 6 Months
Justin J. Anker et al.
BIOLOGICAL PSYCHIATRY (2012)
Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-Cocaine
Junjun Liu et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX
Ashima Saxena et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine
Liu Xue et al.
MOLECULAR PHARMACOLOGY (2011)
Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use
A. Weber et al.
VOX SANGUINIS (2011)
Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine
Wenchao Yang et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Pharmacokinetics and immunologic consequences of repeated administrations of purified heterologous and homologous butyrylcholinesterase in mice
Wei Sun et al.
LIFE SCIENCES (2009)
An albumin-butyrylcholinesterase for cocaine toxicity and addiction: Catalytic and pharmacokinetic properties
Yang Gao et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2008)
Most efficient cocaine hydrolase designed by virtual screening of transition states
Fang Zheng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats
Stephen Brimijoin et al.
NEUROPSYCHOPHARMACOLOGY (2008)
New treatments for cocaine dependence:: a focused review
Laurent Karila et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2008)
Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants
Yongmei Pan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Substrate activation of butyrylcholinesterase and substrate inhibition of acetylcholinesterase by 3,3-dimethylbutyl-N-n-butylcarbamate and 2-trimethylsilyl-ethyl-N-n-butylcarbamate
Shyh-Ying Chiou et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2007)
Human serum butyrylcholinesterase: In vitro and in vivo stability, pharmacokinetics, and safety in mice
A Saxena et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2005)
Computational redesign of human butyrylcholinesterase for anticocaine medication
YM Pan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
First-principle studies of intermolecular and intramolecular catalysis of protonated cocaine
CG Zhan et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)
Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants
A Hamza et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2005)
Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies
MM Meijler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats
Y Gao et al.
MOLECULAR PHARMACOLOGY (2005)
Treating cocaine addiction with viruses
MRA Carrera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
Y Nicolet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Neurobiology of butyrylcholinesterase
S Darvesh et al.
NATURE REVIEWS NEUROSCIENCE (2003)
Re-engineering butyrylcholinesterase as a cocaine hydrolase
H Sun et al.
MOLECULAR PHARMACOLOGY (2002)
DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase
AT Boeck et al.
BIOCHEMICAL PHARMACOLOGY (2002)
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase - Engineering effective butyrylcholinesterase mutants for cocaine detoxication
H Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Efficient particle-mesh Ewald based approach to fixed and induced dipolar interactions
A Toukmaji et al.
JOURNAL OF CHEMICAL PHYSICS (2000)
Fluctuation formulas in molecular-dynamics simulations with the weak coupling heat bath
T Morishita
JOURNAL OF CHEMICAL PHYSICS (2000)