Journal
ALZHEIMERS & DEMENTIA
Volume 15, Issue 1, Pages 168-171Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2018.06.3058
Keywords
Alzheimer's disease; NIA-AA research framework; Model; Systems biology; Common pathway
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Funding
- National Key R&D Program of China [2017YFC1310102]
- National Natural Science Foundation of China [81671040]
- Beijing Municipal Science & Technology Commission [Z151100004015078]
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The new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer's disease conceptual models. However, as a complex disease, a model based on systems-level understanding is needed to accommodate the complex, interacting etiologic pathways and the system-level changes associated with Alzheimer's disease pathogenesis and interventions that are currently known and which will be identified in the future. To accomplish this, the evolution of the structure of the research framework itself should be encouraged. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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