Journal
ALZHEIMERS & DEMENTIA
Volume 14, Issue 11, Pages 1416-1426Publisher
WILEY
DOI: 10.1016/j.jalz.2018.06.3061
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Funding
- Mary Kinross Charitable Trust
- Halpin Trust
- National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care for the South West Peninsula (Pen-CLAHRC)
- NIHR
- National Institute on Aging (NIA)/National Institutes of Health (NIH) [R01 AG051827]
- National Institute of Neurological Disorders and Stroke (NIH/NINDS) [R01 NS102715]
- NIA/NIH [RF1AG055654]
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Introduction: Stroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk. Methods: We searched Medline, PsycINFO, and Embase for studies assessing prevalent or incident stroke versus a no-stroke comparison group and the risk of all-cause dementia. Random effects meta-analysis was used to pool adjusted estimates across studies, and meta-regression was used to investigate potential effect modifiers. Results: We identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all-cause dementia was 1.69 (95% confidence interval: 1.49-1.92; P < .00001; I-2 = 87%). For incident stroke, the pooled risk ratio was 2.18 (95% confidence interval: 1.90-2.50; P < .00001; I-2 = 88%). Study characteristics did not modify these associations, with the exception of sex which explained 50.2% of between-study heterogeneity for prevalent stroke. Discussion: Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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