Journal
ALZHEIMERS & DEMENTIA
Volume 15, Issue 2, Pages 185-193Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2018.09.002
Keywords
Alzheimer's disease; Subjective cognitive decline; AD biomarkers; Medial temporal lobe
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Funding
- EU Joint Program-Neurodegenerative Disease Research (JPND) project
- Germany, Bundesministerium fur Bildung und Forschung (BMBF) [01ED1508]
- Netherlands, The Netherlands Organisation for Health Research and Development
- German Research Council (DFG) [JE 2707/7-1]
- German Center for Neurodegenerative Diseases (Deutsches Zentrum fur Neurodegenerative Erkrankungen, DZNE) [BN012]
- NIHR UCLH Biomedical Research Centre
- research grant on subjective cognitive decline (SCIENCe project: Gieskes Strijbis fonds)
- Spain, Instituto De Salud Carlos III
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Introduction: Previous studies showed associations of brain volume differences and biomarker evidence for Alzheimer's disease (AD) in subjective cognitive decline (SCD). The consistency of this finding across SCD studies has not been investigated. Methods: We studied gray matter volume differences between SCD subjects with and without cerebrospinal fluid biomarker evidence for AD across three European memory clinic samples (German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia study, Amsterdam, Barcelona). Analysis of covariance models with samples and cerebrospinal fluid biomarkers as between-subject factors were calculated. Results: A significant main effect for AD biomarker (A beta(422)- > A beta(42)+) in the left medial temporal lobe (MTL) was found, with the absence of main effects for sample or interaction effects between AD biomarker and sample. This indicates consistent lower left MTL volume across three samples in SCD subjects with abnormal A beta(42) levels. Discussion: Our results support the model that in the presence of AD pathology, SCD corresponds to the late preclinical stage (stage 2 of AD) with smaller MTL volumes. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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