Journal
AGING-US
Volume 10, Issue 11, Pages 3421-3437Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101656
Keywords
miR-150-5p; colorectal cancer; VEGFA; Akt/mTOR
Categories
Funding
- National Nature Science Foundation of of Nanjing Medicine [ZDX16001ZDX16001]
- Innovation team of Jiangsu provincial health-strengthening engineering, science and education [CXTDB2017008]
- Jiangsu Youth Medical Talents Training Project [QNRC2016066, QNRC2016074]
- Nanjing Medical Science and Technique Development Foundation [JQX13003]
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MicroRNA-150-5p (miR-150-5p) has been implicated in tumor initiation and progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain largely unknown. In our study, a decreased miR-150-5p expression in CRC tissues was found to be associated with poor overall survival. Moreover, miR-150-5p inhibited CRC cell proliferation, migration, invasion and angiogenesis in vitro and in vivo, and its inhibitory effect could be reversed by transfection of vascular epithelial growth factor A (VEGFA) expression plasmid. Lastly, we demonstrated that miR-150-5p inactivated VEGFA/VEGFR2 and the downstream Akt/mTOR signaling pathway in CRC. Based on these results, we conclude that miR-150-5p may function as a tumor suppressor in CRC, and miR-150-5p/VEGFA axis may be a potential therapeutic target candidate in CRC treatment.
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