Journal
AGING-US
Volume 10, Issue 11, Pages 3260-3272Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101630
Keywords
Drosophila; hydrogen sulfide; lifespan; locomotor activity; paraquat; hyperthermia; desiccation; starvation
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Funding
- Russian Science Foundation [N 17-74-30030]
- Russian Science Foundation [17-74-30030] Funding Source: Russian Science Foundation
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Recent experimental studies highlighted the role of hydrogen sulfide (H2S) in aging and longevity. The cystathionine B-synthase (CBS) and cystathionine gamma-lyase (CSE) are the key enzymes responsible for H2S production. Here we investigated the geroprotective effects of CSE and CBS overexpression in Drosophila. Overexpression of CSE did not affect a lifespan and decrease (mitochondria) form of CSE) or increase (cytoplasmic form of CSE) age dynamics of locomotor activity, while overexpression of CBS increase median (by 12.5%) and maximum (by 6.9%) lifespan and locomotor activity. Increasing of both CSE and CBS expression levels resulted in thermotolerance, but the resistance to combination of arid and food-free conditions decreased. The resistance to oxidative stress (paraquat) was not affected in flies with overexpression of CBS and cytoplasmic CSE, but decreased in flies overexpressing mitochondrial form of CSE. Thus, transgene overexpression of the CSE and CBS in Drosophila induce similar effects on stress-resistance and locomotor activity, however lifespan extending effect was revealed for CBS overexpression only.
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