Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 361, Issue 1, Pages 214-218Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201801217
Keywords
Oxazolines; Ring-opening; Isoquinolones; Cascade reaction
Categories
Funding
- NSF of China [21572072, 21602064]
- Xiamen Southern Oceanographic Center [15PYY052SF01]
- Huaqiao University
Ask authors/readers for more resources
An atom-economic approach for the synthesis of N-(2-acetoxyalkyl)isoquinolones from oxazolines and alkynes through rhodium(III)-catalyzed auto-tandem reactions involving C-H bond functionalization/C-N bond formation/ring opening/nucleophilic substitution is described. This protocol features high regioselectivity, tolerance of various functional groups, and retention of absolute configuration of chirality. Exploration of the reaction mechanism reveals that Cu(OAc)(2) not only acts as the oxidant, but also provides acetate to promote the reaction in this process.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available