Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 361, Issue 2, Pages 247-264Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201801228
Keywords
carbon dioxide; carboxylation; C-1 building blocks; flow chemistry; gas-liquid reactions; green chemistry
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Funding
- Bill and Melinda Gates Foundation
- Amgen
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Carbon dioxide (CO2) is an attractive building block for organic synthesis that is environmentally friendly. Continuous flow technologies have enabled C-O and C-C bond forming reactions with CO2 that previously were either low-yielding or impossible in batch to afford value-added chemicals. This review describes recent advances in continuous flow as an enabling strategy in utilizing CO2 as a C-1 building block in chemical synthesis.
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