Potassium Persulfate-Mediated Thiocyanation of 2H-Indazole under Iron-Catalysis

Potassium persulfate-mediated thiocyanation of 2H-indazoles has been developed using ammonium thiocyanate as thiocyanating agent under iron-catalysis at room temperature. 2-Aryl-3-thiocyanato-2H-indazoles are synthesized in good yields with a broad substrates scope. This methodology is also applicable for the selenocyanation of 2H-indazoles. The mechanistic study suggests the reaction probably proceeds through a radical pathway.