Journal
ADVANCED MATERIALS
Volume 30, Issue 50, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201802444
Keywords
core-shell; hyperthermia; magnetic interaction; magnetic resonance image; theranostics
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Funding
- Ministry of Science and Technology of Republic of China [NSC 102-2221-E-007-043-MY2]
- Technology Development Program for Academia [H301ARY431]
- NSC [96-2628-E-007-017-MY3, 101-2120-M-007-012-CC1]
- EPSRC [EP/K000225/1]
- EPSRC Small Items of Research Equipment at the University of York ENERGY [EP/K031589/1]
- N8 consortium
- EPSRC [EP/K000225/1] Funding Source: UKRI
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The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core-shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core-shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.
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