Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 52, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201806088
Keywords
Ag2S nanoparticles; infrared bioimaging; nanothermometry; transcranial imaging
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Funding
- Spanish Ministry of Economy and Competitiveness [MAT2016-75362-C3-1-R, MAT2017-85617-R, FIS2015-67367-C2-1-P]
- Instituto de Salud Carlos III [PI16/00812]
- COST Action [CM1403]
- Comunidad Autonoma de Madrid [B2017/BMD-3867RENIM-CM, S2013/MIT-2740]
- European Commission (NanoTBTech)
- European Union
- Spanish Ministry of Economy and Competitiveness
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Despite attracting increased attention from clinicians, brain temperature distribution, fluctuations, and changes in response to external stimuli are still largely unknown and refractory to conventional temperature-probing approaches. Fluorescence nanothermometry in the second near-infrared window (NIR-II, 1000-1700 nm), as shown here, can provide contactless brain thermal sensing through the scalp and skull in real time with a subdegree resolution. As a proof of concept, Ag2S nanothermometers have been used to monitor brain thermoregulation in a cooling/heating process and temperature changes associated to a barbiturate coma.
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