4.8 Article

Euryale Ferox Seed-Inspired Superlubricated Nanoparticles for Treatment of Osteoarthritis

Journal

ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 4, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201807559

Keywords

bioinspired; lubrication; nanoparticles; osteoarthritis; photopolymerization

Funding

  1. National Key Research and Development Program of China [2018YFC1106200, 2018YFC1106204]
  2. National Natural Science Foundation of China [51675296, 51873107, 81572099]
  3. Ng Teng Fong Charitable Foundation [202-276-132-13]
  4. Research Fund of State Key Laboratory of Tribology, Tsinghua University, China [SKLT2018B08]
  5. Shanghai Science and Technology Commission [18ZR1434200, 17140900102]
  6. Shanghai Municipal Education CommissionGaofeng Clinical Medicine Grant Support [20171906]
  7. Shanghai Jiao Tong University Medical and Research Program [ZH2018ZDA04]
  8. Major Program for the Fundamental Research of Shanghai [2014ZYJB0302]
  9. Jane and Aatos Erkko Foundation [4704010]
  10. Academy of Finland [297580]
  11. Sigrid Juselius Foundation [28001830K1, 4704580]
  12. HiLIFE Research Funds

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Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a slippery aril and a hard coat containing starchy kernel, a novel superlubricated nanoparticle, namely poly (3-sulfopropyl methacrylate potassium salt)-grafted mesoporous silica nanoparticles (MSNs-NH2@PSPMK), is biomimicked and synthesized via a one-step photopolymerization method. The nanoparticles are endowed with enhanced lubrication by the grafted PSPMK polyelectrolyte polymer due to the formation of tenacious hydration layers surrounding the negative charges, and simultaneously are featured with effective drug loading and release behavior as a result of the sufficient mesoporous channels in the MSNs. When encapsulated with an anti-inflammatory drug diclofenac sodium (DS), the lubrication capability of the superlubricated nanoparticles is improved, while the drug release rate is sustained by increasing the thickness of PSPMK layer, which is simply achieved via adjustment of the precursor monomer concentration in the photopolymerization process. Additionally, the in vitro and in vivo experimental results show that the DS-loaded MSNs-NH2@PSPMK nanoparticles effectively protect the chondrocytes from degeneration, and thus, inhibit the development of osteoarthritis.

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