Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 139, Issue -, Pages 71-82Publisher
ELSEVIER
DOI: 10.1016/j.addr.2018.12.001
Keywords
Stimuli-responsiveness; Insulin delivery; Alternative routes; Glucose sensing; Diabetes mellitus
Categories
Funding
- Ministry of Science and Technology of Taiwan, ROC [MOST 107-2119-M-007-016]
- Ministry of Education of Taiwan, ROC [MOE 107QR00115]
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The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery. (C) 2018 Elsevier B.V. All rights reserved.
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