Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 138, Issue -, Pages 326-343Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.10.004
Keywords
Magnetic nanoparticles; Liposomes; Gene therapy; Switchable gates; Hydrogel; Polymer; Cancer
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Funding
- Spanish MINECO [SAF2014-54763-C2-2-R, BIO2017-84246-C21-R]
- Fondo Social de la DGA (grupos DGA)
- COST Action [TD1402]
- European Commission through the M-ERA.NET COFUND project MagicCellGene [PCIN-2017-060]
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Magnetic nanoparticles (MNPs) are promising tools for a wide array of biomedical applications. One of their most outstanding properties is the ability to generate heat when exposed to alternating magnetic fields, usually exploited in magnetic hyperthermia therapy of cancer. In this contribution, we provide a critical review of the use of MNPs and magnetic hyperthermia as drug release and gene expression triggers for cancer therapy. Several strategies for the release of chemotherapeutic drugs from thermo-responsive matrices are discussed, providing representative examples of their application at different levels (from proof of concept to in vivo applications). The potential of magnetic hyperthermia to promote in situ expression of therapeutic genes using vectors that contain heat-responsive promoters is also reviewed in the context of cancer gene therapy. (C) 2018 Published by Elsevier B.V.
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