Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 139, Issue 2, Pages 185-193Publisher
WILEY
DOI: 10.1111/acps.12978
Keywords
suicide, attempted; depressive disorder, major; zonulin; intestinal fatty acid binding protein; intestinal permeability
Categories
Funding
- Swedish Research Council [2015-00387]
- Marie Sklodowska Curie Actions [INCA 600398]
- Swedish Society of Medicine
- Soderstrom-Konigska Foundation
- Sjobring Foundation
- OM Persson Foundation
- province of Scania (Sweden) state grants (ALF)
- Swedish Research Council [2015-00387] Funding Source: Swedish Research Council
Ask authors/readers for more resources
Objective Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the 'leaky gut hypothesis', increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation. Method We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery-angstrom sberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments. Results The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = -0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05). Conclusion The 'leaky gut hypothesis' may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available