Journal
ACS NANO
Volume 13, Issue 1, Pages 408-420Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b06563
Keywords
self-assembly; multifunctional supernanoparticles; second biological window; bimodal imaging; dual-modal heating
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada [NSERC: RGPIN-2015-06756]
- Fonds de Recherche du Quebec - Nature et Technologies [FRQNT: 2014-PR-174462]
- Ministere de l'Education, du Loisir et du Sport du Quebec [193353, 255072, 257149]
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Developing multifunctional therapeutic and diagnostic (theranostic) nanoplatforms is critical for addressing challenging issues associated with cancers. Here, self-assembled supernanoparticles consisting of superparamagnetic Fe3O4 nanoparticles and photo luminescent PbS/CdS quantum dots whose emission lies within the second biological window (II-BW) are developed. The proposed self assembled Fe3O4 and PbS/CdS (II-BW) supernanoparticles [SASNs (II-BW)] exhibit outstanding photoluminescence detectable through a tissue as thick as 14 mm, by overcoming severe light extinction and concomitant autofluorescence in II-BW, and significantly enhanced T-2 relaxivity (282 mM(-1) s(-1), ca. 4 times higher than free Fe3O4 nanoparticles) due to largely enhanced magnetic field inhomogeneity. On the other hand, SASNs (II-BW) possess the dual capacity to act as both magnetothermal and photothermal agents, overcoming the main drawbacks of each type of heating separately. When SASNs (II-BW) are exposed to the dual-mode (magnetothermal and photothermal) heating, the thermal energy transfer efficiency is amplified 7-fold compared with magnetic heating alone. These results, in hand with the excellent photo- and colloidal stability, and negligible cytotoxicity, demonstrate the potential use of SASNs (II-BW) for deep-tissue bimodal (magnetic resonance and photoluminescence) in vivo imaging, while simultaneously providing the possibility of SASNs (II-BW)-mediated amplified dual-mode heating treatment for cancer therapy.
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