Journal
ACS NANO
Volume 13, Issue 1, Pages 284-294Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b05982
Keywords
titanium carbide nanocomposites; surface modification; dual-modal imaging; combined therapy; the synergistic effect
Categories
Funding
- National Research Programs of China [2016YFA0201200]
- National Natural Science Foundation of China [51525203, 51572180, 21705054]
- open funds of the State Key Laboratory of Agricultural Microbiology [AMLKF201809]
- Jiangsu Natural Science Fund for Distinguished Young Scholars [BK20130005, BK20170063]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Multifunctional nanoplatforms with special advantages in the diagnosis and treatment of cancer have been widely explored in nanomedicine. Herein, we synthesize two-dimensional core-shell nanocomposites (Ti3C2@Au) via a seed-growth method starting from the titanium carbide (Ti3C2) nanosheets, a classical type of MXene nanostructure. After growing gold on the surface of Ti3C2 nanosheets, the stability and biocompatibility of the nanocomposites are greatly improved by the thiol modification. Also importantly, the optical absorption in the near-infrared region is enhanced. Utilizing the ability of the high optical absorbance and strong X-ray attenuation, the synthesized Ti3C2@Au nanocomposites are used for photoacoustic and computed tomography dual-modal imaging. Importantly, the mild photothermal effect of the Ti3C2@Au nanocomposites could improve the tumor oxygenation, which significantly enhances the radiotherapy. No obvious long-term toxicity of the nanocomposites is found at the injected dose. This work highlights the promise of special properties of MXene-based multifunctional nanostructures for cancer theranostics.
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