Journal
ACS NANO
Volume 12, Issue 12, Pages 12347-12356Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b06321
Keywords
transition metal dichalcogenides (TMDs); aqueous exfoliation; monolayer nanosheets; photothermal nanocarrier; antibiofilm activity
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Funding
- National Natural Science Foundation of China [21534009]
- Fundamental Research Funds for the Central Universities [2017XZZX001-03B]
- Research Computing Center in College of Chemical and Biological Engineering at Zhejiang University
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Transition metal dichalcogenide (TMD) nanosheets have evoked enormous research enthusiasm and have shown increased potentials in the biomedical field. However, a great challenge lies in high-throughput, large-scale, and eco-friendly preparation of TMD nanosheet dispersions with high quality. Herein, we report a universal polyphenol-assisted strategy to facilely exfoliate various TMDs into monolayer or few-layer nanosheets. By optimizing the exfoliation condition of molybdenum disulfide (MoS2), the yield and concentration of as-exfoliated nanosheets are up to 60.5% and 1.21 mg/mL, respectively. This is the most efficient aqueous exfoliation method at present and is versatile for the choices of polyphenols and TMD nanomaterials. The as-exfoliated MoS2 nanosheets possess superior biomedical stability as nanocarriers to load antibiotic drugs. They show a high photothermal conversion effect and thus induce a synergetic effect of chemotherapy and photothermal therapy to harvest enhanced antibiofilm activity under near-infrared (NIR) light. All these results offer an appealing strategy toward the synthesis and application of ultrathin TMD nanosheets, with great implications for their development.
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