Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 3, Pages 2849-2859Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b19228
Keywords
self-assembly; peptide hydrogel; self-healing; biocompatible; antibacterial; anti-inflammatory
Funding
- CSIR, New Delhi, India [01(2936)/18/EMR-II]
- CSIR, India
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The growing area of biomaterial sciences has attracted broad attention in recent years in the development of peptide-based biocompatible materials with inherent therapeutic potentials. Here, we developed an Amoc (9-anthracenemethoxycarbonyl)-capped dipeptide-based biocompatible, injectable, thixotropic, and self-healable hydrogel. In vitro cytotoxicity of the hydrogel was investigated with the human embryonic kidney cell (HEK293) line. We observed that the synthesized peptide is noncytotoxic. The hydrogel showed an antibacterial efficacy against Gram-positive and Gram-negative bacteria. In vivo anti-inflammatory activity of the hydrogel was investigated using the rat air pouch model of acute inflammation. The major parameters considered for the anti-inflammatory study were exudate volume, total and differential white blood cell count, tissue histology, and lipid peroxidation assay. These experimental data suggest biocompatibility and potential therapeutic applications of peptide hydrogel in inflammation.
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