Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 51, Pages 44221-44225Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b19153
Keywords
DNA origami; gold nanorods; chiral plasmonics; aptamers; biosensing
Funding
- Academy of Finland [308992]
- European Union [71364]
- Academy of Finland (AKA) [308992, 308992] Funding Source: Academy of Finland (AKA)
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Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.
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