Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 49, Pages 42165-42174Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b17660
Keywords
metal-organic frameworks; drug delivery; size-controlled synthesis; radiochemistry; PET imaging; theranostics
Funding
- College of Chemistry and Molecular Engineering, Peking University
- Peking-Tsinghua Center for Life Sciences, Peking University
- National Natural Science Foundation of China [NSFC 21778003]
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Recently, metal-organic frameworks (MOFs) or coordination polymers have shown great potential for drug delivery, yet little has been done to study how particle size affects their tumor targeting and other in vivo features. This plight is probably due to two challenges: (1) the lack of a biocompatible method to precisely control the size of drug loaded MOFs and (2) the lack of a robust and facile radiolabeling technique to trace particles in vivo. Here, we report a one-pot, rapid, and completely aqueous approach that can precisely tune the size of drug-loaded MOF at room temperature. A chelator-free Cu-64-labeled method was developed by taking the advantage of this rapid and aqueous synthesis. Cancer cells were found to take drug-loaded MOFs in a size-dependent manner. The in vivo biodistribution of drug loaded MOF was analyzed with positron emission tomography imaging, which, as far as we know, was used for the first time to quantitatively evaluate MOF in living animals, unveiling that 60 nm MOF showed longer blood circulation and over 50% higher tumor accumulation than 130 nm MOF. Altogether, this size-controlled method helps to find the optimal size of MOF as a drug carrier and opens new possibilities to construct multifunctional delivery systems for cancer theranostics.
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