Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 49, Pages 41917-41923Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b12351
Keywords
nanoparticles; dual functionalization; corona free nanoparticles; hemolysis; cytotoxicity
Funding
- FAPESP [2014/22322-2, 2015/25406-5, 2013/22429-9, BEPE 2015/21918-1]
- LNLS
- LNNano
- CNPq [309107/2014-8]
- NIH [GM077173, EB022641]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/25406-5] Funding Source: FAPESP
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Protein coronas form on the surfaces of nanomaterials in biological fluids. This layer of proteins affects the properties of nanomaterials, altering their behavior and masking engineered functionality. The use of nonfouling moieties reduces or prevents corona formation; however, these ligands typically complicate functionalization. We present here a surface modification strategy for silica nanoparticles using specific molar ratios of zwitterionic and amine moieties. Through proper balance of ligands, we were able to generate particles that featured reactive handles, while retaining nonfouling properties, high hemocompatibility, and low cytotoxicity.
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