Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 45, Pages 38833-38844Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b15678
Keywords
WO3-x@gamma-poly-l-glutamic acid nanoparticles; photoacoustic imaging; chemodynamic therapy; photothermal therapy; cancer
Funding
- National Natural Science Foundation of China [21601124, 21671135]
- Program of Young Eastern Scholar from Shanghai Institutions of Higher Learning [QD2015038]
- Shanghai Rising-Star Program [17QA1402600]
- International Joint Laboratory on Resource Chemistry (IJLRC)
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Synergistic treatment strategies for cancer have attracted increasing attention owing to their enhanced therapeutic effects compared with monotherapy. Chemodynamic therapy (CDT) is an emerging and thriving in situ treatment for cancer owing to its high regioselectivity and activation only by endogenous substances. However, the therapeutic effects of CDT are hindered by low reaction speeds. Here, ultrasmall WO3-x@gamma-poly-L-glutamic acid (WO3-x@gamma-PGA) nanoparticles (NPs) with good photo acoustic and photothermal properties were prepared, and their chemodynamic performance based on a Fenton-like reaction was explored due to its good catalytic effect. The synergistic treatment effect was also investigated by photothermal-enhanced CDT based on single WO3-x@gamma-PGA NPs using a penetrating near-infrared-II laser both in vitro and in vivo. This work provides an effective treatment for cancer and further develops the CDT.
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