Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 43, Pages 36615-36621Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b15452
Keywords
metal-organic framework; Alzheimer's disease; phototherapy; PCN-224; amyloid-beta
Funding
- National Natural Science Foundation of China (NSFC) [81471747, 31771077]
- Hong Kong Polytechnic University Internal Fund [1-ZVJ7, 1-YW1L]
- University Research Facility in Life Sciences of the Hong Kong Polytechnic University
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The aberrant aggregation of amyloid-beta peptide (A beta) in the brain has been considered as the major pathological hallmark of Alzheimer's diseases (AD). Inhibition of A beta aggregation is considered as an attractive therapeutic intervention for alleviating amyloid-associated neurotoxicity. Here, we report the near-infrared light (NIR)-induced suppression of A beta aggregation and reduction of A beta-induced cytotoxicity via porphyrinic metal-organic framework (MOF) PCN-224 nanoparticles. PCN-224 nanoparticles are hydrothermally synthesized by coordinating tetra-kis(4-carboxyphenyl)porphyrin (TCPP) ligands with zirconium. The PCN-224 nanoparticles show high photo-oxygenation efficiency, good biocompatibility, and high stability. The study reveals that the porphyrinic MOF-based nanoprobe activated by NIR light could successfully inhibit self-assembly of monomeric A beta into a beta-sheet-rich structure. Furthermore, photoexcited PCN-224 nanoparticles also significantly reduce A beta-induced cytotoxicity under NIR irradiation.
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