Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 1, Pages 37-42Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b18288
Keywords
long noncoding RNA; nanostructure; MALAT1; cancer metastasis; gene therapy
Funding
- National Natural Science Foundation of China [21621003, 21327806, 31430031, 51373117, 31225009, 31761133013]
- Chinese Academy of Science [121D11KYSB20130006, XDA09030301]
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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA) located in the cell nucleus, is a critical regulator of tumor cell migration. Antisense oligonucleotides (ASOs), which can downregulate the expression level of specific RNAs, have been used in clinical for disease treatment. Herein, we constructed MALAT1-specific ASO and nucleus-targeting TAT peptide cofunctionalized Au nanoparticles, namely, ASO-Au-TAT NPs, which stabilized the fragile ASOs, enhanced nuclear internalization, and exhibited good biocompatibility. After treatment with the ASO-Au-TAT NPs, A549 lung cancer cells showed a greatly reduced MALAT1 expression level and decreased migration ability in vitro. Moreover, the ASO-Au-TAT NPs significantly reduced metastatic tumor nodule formation in vivo. Our results demonstrate that the ASO-Au-TAT nanostructures (NSs) have great potential for treatment of cancer metastasis.
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