Journal
NATURE BIOMEDICAL ENGINEERING
Volume 3, Issue 1, Pages 37-46Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-018-0300-4
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Funding
- Ryan Fellowship
- Northwestern University International Institute for Nanotechnology
- Beckman Institute Postdoctoral Fellowship at UIUC
- Cancer Center Support grant (National Cancer Institute) [P30 CA060553]
- National Research Foundation of Korea [NRF-2017M1A2A2048880, NRF-2018M3A7B4071109]
- Yonsei University [RMS2 2018-22-0028]
- NSF [1400169, 1534120, 1635443]
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Pressures in the intracranial, intraocular and intravascular spaces are clinically useful for the diagnosis and management of traumatic brain injury, glaucoma and hypertension, respectively. Conventional devices for measuring these pressures require surgical extraction after a relevant operational time frame. Bioresorbable sensors, by contrast, eliminate this requirement, thereby minimizing the risk of infection, decreasing the costs of care and reducing distress and pain for the patient. However, the operational lifetimes of bioresorbable pressure sensors available at present fall short of many clinical needs. Here, we present materials, device structures and fabrication procedures for bioresorbable pressure sensors with lifetimes exceeding those of previous reports by at least tenfold. We demonstrate measurement accuracies that compare favourably to those of the most sophisticated clinical standards for non-resorbable devices by monitoring intracranial pressures in rats for 25 days. Assessments of the biodistribution of the constituent materials, complete blood counts, blood chemistry and magnetic resonance imaging compatibility confirm the biodegradability and clinical utility of the device. Our findings establish routes for the design and fabrication of bioresorbable pressure monitors that meet requirements for clinical use.
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