Journal
NATURE BIOMEDICAL ENGINEERING
Volume 2, Issue 12, Pages 894-906Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-018-0273-3
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Funding
- Leona M. and Harry B. Helmsley Charitable Trust Foundation [2015PG-T1D063]
- Juvenile Diabetes Research Foundation (JDRF) [17-2007-1063]
- National Institutes of Health [EB000244, EB000351, DE013023, CA151884]
- JDRF postdoctoral fellowship [3-PDF-2015-91-A-N]
- National Institutes of Health (NIH/NIDDK) [R01DK091526]
- Chicago Diabetes Project
- 100 Talents Program of Sun Yat-Sen University [76120-18821104]
- 1000 Talents Youth Program of China
- National Natural Science Foundation of China [51705543, 61771498, 31530023]
- Science and Technology Program of Guangzhou, China [20180310097]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R37EB000244, R01EB000244] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE013023] Funding Source: NIH RePORTER
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Continuous glucose monitors (CGMs), used by patients with diabetes mellitus, can autonomously track fluctuations in blood glucose over time. However, the signal produced by CGMs during the initial recording period following sensor implantation contains substantial noise, requiring frequent recalibration via finger-prick tests. Here, we show that coating the sensor with a zwitterionic polymer, found via a combinatorial chemistry approach, significantly reduces signal noise and improves CGM performance. We evaluated the polymer-coated sensors in mice as well as in healthy and diabetic non-human primates, and show that the sensors accurately record glucose levels without the need for recalibration. We also show that the coated sensors significantly abrogated immune responses, as indicated by histology, fluorescent whole-body imaging of inflammation-associated protease activity and gene expression of inflammation markers. The polymer coating may allow CGMs to become standalone measuring devices.
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