Journal
MICROSCOPY
Volume 65, Issue 1, Pages 57-67Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jmicro/dfv370
Keywords
3D reconstruction; SNR; noise
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Funding
- National Institutes of Health [R01-NS021501]
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Single-particle reconstruction is the process by which 3D density maps are obtained from a set of low-dose cryo-EM images of individual macromolecules. This review considers the fundamental principles of this process and the steps in the overall workflow for single-particle image processing. Also considered are the limits that image signal-to-noise ratio places on resolution and the distinguishing of heterogeneous particle populations.
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