Journal
COMPUTATIONAL PARTICLE MECHANICS
Volume 1, Issue 2, Pages 211-227Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s40571-014-0017-4
Keywords
Cell mechanics; Subcellular element model; Cell growth; Cell migration; Cell signaling
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We present a discrete particle method to model biological processes from the sub-cellular to the inter-cellular level. Particles interact through a parametrized force field to model cell mechanical properties, cytoskeleton remodeling, growth and proliferation as well as signaling between cells. We discuss the guiding design principles for the selection of the force field and the validation of the particle model using experimental data. The proposed method is integrated into a multiscale particle framework for the simulation of biological systems.
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