Journal
VIROLOGICA SINICA
Volume 33, Issue 4, Pages 335-344Publisher
SPRINGER
DOI: 10.1007/s12250-018-0045-y
Keywords
Porcine reproductive and respiratory syndrome virus (PRRSV); Alternative polyadenylation (APA); Differentially expressed genes (DEGs); Whole-genome transcriptome analysis
Categories
Funding
- Natural Science Foundation of Guangdong Province [2014A030312011]
- Guangzhou Science and Technology Plan [201804020039]
Ask authors/readers for more resources
Porcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses to the global pig industry. Alternative polyadenylation (APA) is a mechanism that diversifies gene expression, which is important for tumorigenesis, development, and cell differentiation. However, it is unclear whether APA plays a role in the course of PRRSV infection. To address this issue, in this study we carried out a whole-genome transcriptome analysis of PRRSV-infected Marc-145 African green monkey kidney cells and identified 185 APA switching genes and 393 differentially expressed genes (DEGs). Most of these genes were involved in cellular process, metabolism, and biological regulation, and there was some overlap between the two gene sets. DEGs were found to be more directly involved in the antiviral response than APA genes. These findings provide insight into the dynamics of host gene regulation during PRRSV infection and a basis for elucidating the pathogenesis of PRRSV.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available