Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 460, Issue 1, Pages 72-81Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2015.01.137
Keywords
Calcium; Mitochondria; Necrosis; Apoptosis; Autophagy; Reactive oxygen species
Categories
Funding
- Swedish Research Council
- Swedish Cancer Society
- Stockholm Cancer Society
- Swedish Childhood Cancer Foundation
- Russian Science Foundation [14-25-00056, 14-15-00463]
- Russian Science Foundation [14-15-00463, 14-25-00056] Funding Source: Russian Science Foundation
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The calcium ion has long been known to play an important role in cell death regulation. Hence, necrotic cell death was early associated with intracellular Ca2+ overload, leading to mitochondrial permeability transition and functional collapse. Subsequent characterization of the signaling pathways in apoptosis revealed that Ca2+/calpain was critically involved in the processing of the mitochondrially localized, Apoptosis Inducing Factor. More recently, the calcium ion has been demonstrated to play important regulatory roles also in other cell death modalities, notably autophagic cell death and anoikis. In this review, we summarize current knowledge about the mechanisms involved in Ca2+ regulation of these various modes of cell death with a focus on the importance of the mitochondria. (C) 2015 Elsevier Inc. All rights reserved.
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