Journal
DIABETES & METABOLISM JOURNAL
Volume 38, Issue 1, Pages 13-24Publisher
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2014.38.1.13
Keywords
Diabetes mellitus; Endocrine disrupting chemicals; Endocrine disruptors; Insulin; Insulin resistance; Insulin signaling; Pollution
Categories
Funding
- National Institutes of Health [K08-ES019176, R21-ES021354]
- Diabetes Research and Training Center [P60-DK020595]
- Central Society for Clinical and Translational Research
- Brinson Foundation
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The burgeoning epidemic of metabolic disease causes significant societal and individual morbidity and threatens the stability of health care systems around the globe. Efforts to understand the factors that contribute to metabolic derangements are critical for reversing these troubling trends. While excess caloric consumption and physical inactivity superimposed on a susceptible genetic background are central drivers of this crisis, these factors alone fail to fully account for the magnitude and rapidity with which metabolic diseases have increased in prevalence worldwide. Recent epidemiological evidence implicates endocrine disrupting chemicals in the pathogenesis of metabolic diseases. These compounds represent a diverse array of chemicals to which humans are exposed via multiple routes in adulthood and during development. Furthermore, a growing ensemble of animal- and cell-based studies provides preclinical evidence supporting the hypothesis that environmental contaminants contribute to the development of metabolic diseases, including diabetes. Herein are reviewed studies linking specific endocrine disruptors to impairments in glucose homeostasis as well as tying these compounds to disturbances in insulin secretion and impairments in insulin signal transduction. While the data remains somewhat incomplete, the current body of evidence supports the hypothesis that our chemically polluted environment may play a contributing role in the current metabolic crisis.
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