Journal
DIABETES & METABOLISM JOURNAL
Volume 36, Issue 3, Pages 167-180Publisher
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2012.36.3.167
Keywords
Diabetes mellitus; Retinoid; Rexinoid
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Retinoid acid is a metabolite of vitamin A and functions as an important factor in cell survival, differentiation and death. Most previous studies on retinoid metabolism have focused on its association with cancer, hematologic and dermatologic disorders. Given the special concern over the recent increase in the prevalence of diabetes worldwide, the role of retinoid metabolism on glucose metabolism and insulin resistance in the human body is of marked importance. Therefore, in this issue, we review the literature on the association of retinoid metabolism with glucose tolerance, with regard to insulin secretion, pancreatic autoimmunity, insulin sensitivity and lipid metabolism. Further, we tried to assess the possibility of using retinoids as a novel therapeutic strategy for diabetes.
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