Journal
PHARMACEUTICS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics10040167
Keywords
drug delivery systems; silica-based particles; calcium carbonate; calcium phosphate; in vitro and in vivo delivery; drug loading
Categories
Funding
- Russian Science Foundation [17-19-01637, SP-1576.2018.4]
- Russian Foundation for Basic Research [18-015-00100]
- Tomsk Polytechnic University Competitiveness Enhancement Program
- Russian Science Foundation [17-73-10023, 17-19-01637] Funding Source: Russian Science Foundation
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Porous inorganic nanostructured materials are widely used nowadays as drug delivery carriers due to their adventurous features: suitable architecture, large surface area and stability in the biological fluids. Among the different types of inorganic porous materials, silica, calcium carbonate, and calcium phosphate have received significant attention in the last decade. The use of porous inorganic materials as drug carriers for cancer therapy, gene delivery etc. has the potential to improve the life expectancy of the patients affected by the disease. The main goal of this review is to provide general information on the current state of the art of synthesis of the inorganic porous particles based on silica, calcium carbonate and calcium phosphate. Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound). Moreover, the diverse compounds to deliver with silica, calcium carbonate and calcium phosphate particles, ranging from the commercial drugs to genetic materials are also discussed.
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