Journal
PHARMACEUTICS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics10030131
Keywords
biopharmaceuticals; drying technology; protein stability; bioavailability; pharmacokinetics
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2018R1A2B3004266]
- Technology Innovation Program - Ministry of Trade, Industry & Energy (MOTIE, Korea) [20000265]
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Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide enhanced bioavailability, improved storage stability, as well as expanded alternatives to parenteral administration. Although numerous drying methods have been used for preparing dried protein powders, choosing a suitable drying technique remains a challenge. In this review, the most frequent drying methods, such as freeze drying, spray drying, spray freeze drying, and supercritical fluid drying, for improving the stability and bioavailability of therapeutic proteins, are discussed. These technologies can prepare protein formulations for different applications as they produce particles with different sizes and morphologies. Proper drying methods are chosen, and the critical process parameters are optimized based on the proposed route of drug administration and the required pharmacokinetics. In an optimized drying procedure, the screening of formulations according to their protein properties is performed to prepare a stable protein formulation for various delivery systems, including pulmonary, nasal, and sustained-release applications.
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