Journal
FRONTIERS IN ONCOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2013.00147
Keywords
cytoplasmic PML; TGF-ss; apoptosis; antiviral response; tumorigenesis
Categories
Funding
- NIH ROI
- CPRIT
- MD Anderson Cancer Center Prostate SPORE Career Development
- NATIONAL CANCER INSTITUTE [P50CA140388, R01CA136787, R01CA149321] Funding Source: NIH RePORTER
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The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PMLNBs). PMLNBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. The cytoplasmic PML (cPML) could be originally derived from the retention of exported nuclear PML (nPML). In addition, bona fide cPML isoforms devoid of nuclear localization signal (NLS) have also been identified. Recently, emerging evidence showed that cPML performs its specific cellular functions in tumorigenesis, glycolysis, antiviral responses, laminopothies, and cell cycle regulation. In this review, we will summarize the emerging roles of cPML in cellular functions.
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