Journal
FRONTIERS IN ONCOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2013.00251
Keywords
ovarian cancer; extracellular matrix; platinum-sensitive recurrence; platinum resistance; cancer stem cell
Categories
Funding
- Department of Defense Ovarian Cancer Academy [W81XWH-10-1-0386]
- University of Alabama at Birmingham Center for Clinical and Translational Science [5UL1RR025777]
- Department of Defense Ovarian Cancer Research Academy [W81XWH-10-10461]
- National Science Foundation [I1S1117153]
- National Institutes of Health [P50 CA136393]
- [CA123249]
- Direct For Computer & Info Scie & Enginr
- Div Of Information & Intelligent Systems [1117153] Funding Source: National Science Foundation
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Despite several advances in the understanding of ovarian cancer pathobiology, in terms of driver genetic alterations in high-grade serous cancer, histologic heterogeneity of epithelial ovarian cancer, cell-of-origin for ovarian cancer, the survival rate from ovarian cancer is disappointingly low when compared to that of breast or prostate cancer. One of the factors contributing to the poor survival rate from ovarian cancer is the development of chemotherapy resistance following several rounds of chemotherapy. Although unicellular drug resistance mechanisms contribute to chemotherapy resistance, tumor microenvironment and the extracellular matrix (ECM), in particular, is emerging as a significant determinant of a tumor's response to chemotherapy. In this review, we discuss the potential role of the tumor microenvironment in ovarian cancer recurrence and resistance to chemotherapy. Finally, we propose an alternative view of platinum-sensitive recurrence to describe a potential role of the ECM in the process.
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