Journal
FRONTIERS IN ONCOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2013.00171
Keywords
PML; senescence; SUMO; tumor suppression; p53
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Funding
- INSERM
- CNRS
- Universite Paris Diderot, Institut Universitaire de France
- Ligue Contre le Cancer
- Institut National du Cancer
- Saint Louis Institute
- PACRI (ANR)
- Association pour la Recherche contre le Cancer
- Canceropole Ile de France
- European Research Council
- Ligue Nationale contre le Cancer
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Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation... there are multiple PMLrelated issues. Here we review the reciprocal interactions between PML, senescence, and SUMOylation, notably in the context of cellular transformation.
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