Journal
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 9, Issue 4, Pages 163-175Publisher
HONG KONG ASIAMED PUBLISH HOUSE
DOI: 10.1016/j.ajps.2014.05.002
Keywords
Polymorphs; Polymorph screening; Polymorph selection; Polymorph preparation
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Funding
- Ministry of Food and Drug Safety and Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [14172MFDS189, 2014R1A1A1006429]
- National Research Foundation of Korea [2014R1A1A1006429] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery and development. This review introduces the basic concepts of What is polymorphism?, addresses a fundamental question of Why do polymorphs form?, and provides practical guidelines of How to prepare polymorphs? How to evaluate the relative thermodynamic stability between polymorphs?, and How to analyze polymorphs?. Moreover, case studies of pharmaceutically important polymorphs are provided. (C) 2014 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. All rights reserved.
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