Journal
CANCERS
Volume 10, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cancers10100364
Keywords
chemotherapy; anticancer drug; camptothecin; PARP inhibitor; radiotherapy; sensitizer; DNA repair; apoptosis; checkpoint response
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Funding
- MEXT KAKENHI [20770136]
- Grants-in-Aid for Scientific Research [20770136] Funding Source: KAKEN
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Radiation and certain anticancer drugs damage DNA, resulting in apoptosis induction in cancer cells. Currently, the major limitations on the efficacy of such therapies are development of resistance and adverse side effects. Sensitization is an important strategy for increasing therapeutic efficacy while minimizing adverse effects. In this manuscript, we review possible sensitization strategies for radiation and anticancer drugs that cause DNA damage, focusing especially on modulation of damage repair pathways and the associated reactions.
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