Journal
CANCERS
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cancers10080264
Keywords
SUMOylation; TGF beta; EMT; cancer
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Protein post-translational modification by the small ubiquitin-like modifier (SUMO), or SUMOylation, can regulate the stability, subcellular localization or interactome of a protein substrate with key consequences for cellular processes including the Epithelial-Mesenchymal Transition (EMT). The secreted protein Transforming Growth Factor beta (TGF beta) is a potent inducer of EMT in development and homeostasis. Importantly, the ability of TGF beta to induce EMT has been implicated in promoting cancer invasion and metastasis, resistance to chemo/radio therapy, and maintenance of cancer stem cells. Interestingly, TGF beta-induced EMT and the SUMO system intersect with important implications for cancer formation and progression, and novel therapeutics identification.
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