Journal
CANCERS
Volume 6, Issue 4, Pages 2049-2071Publisher
MDPI AG
DOI: 10.3390/cancers6042049
Keywords
chromatin; gene regulation; cyclins; post-translational modifications; cancer; salivary gland; epithelia; differentiation; RNA splicing; signaling
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Funding
- NIH grants [R01CA170250, R01DE023222]
- NIGMS IRACDA fellowship award [K12GM088021]
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This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.
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